It is an old idea to explore the possible association of disease with genetic markers (for example human blood groups), but it is a relatively new notion that there is likely to be a causal relationship between resistance to a given disease and alleles of a polymorphic cell msnbrane system. - This recent notion stems fran the fundamentally important discovery in mice by Zinkemagel and Doherty (1974) that the function of cytotoxic T lymphocytes or T killer cells, is critically dependent on antigens belonging to H-2, which is the major histocompatibility complex (MHC) of the mouse.
Proceedings of the World Congress on Genetics Applied to Livestock Production, Volume 5. Plenary sessions, , 164–174, 1982
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