Abstract

Genetic-toxicological evaluation of N-chloropiperidine, based on Ames' Salmonella test and host-mediated assay, demonstrated that N-chloropiperidine (NCP) is a direct acting m u t agen. 1 Equ a l l y significant was the observation that tester strains that detected mutations arising from base pair substitution, were the only strains that showed p o s i t i v e response to NCP. The specificity of the mutant Salmonella strains'to the mutagenic action of NCP, coupled with the observed correspondence in the toxicity or m u t a g e n i c i t y profile der i v e d from _i_n vivo and iji vitro studies,2»3 suggests that in solution or Jji vivo NCP forms similar reaction product(s) with cellular or tissue macro- molecule(s).

M. A Bempong

Proceedings of the World Congress on Genetics Applied to Livestock Production, Volume 7. Symposia (1), , 101–109, 1982
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