Computer simulations using additive and dominance models were carried out to investigate the effect of different distributions of gene frequency in base populations on the rate of response to selection in synthetic lines derived from them.
From 5 base populations, synthetic lines were founded with selected individuals from the best two lines or from all five lines. These were compared with the best line.
Selection in a synthetic line is most efficient if one constituent population has a low frequency for a favourable gene common in other populations, is moderately efficient if gene frequencies of favoured alleles are generally low, and is least efficient if gene frequencies are generally intermediate.

B. Gunawan, J. W James

Proceedings of the World Congress on Genetics Applied to Livestock Production, Volume XII. Biotechnology, selection experiments, parameter estimation, design of breeding systems, management of genetic resources., , 328–332, 1986
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