Bull seminal ribonuclease (AS RNase) and phospholipid binding protein-haemolytic factor (PBP) are proteins exhibiting immunosuppressive activity isolated from seminal vesicle fluid. Both proteins are synthesized in ductus deferens and seminal vesicles and AS RNase also in cauda epididymidis under the effector influence of androgens. AS RNase has no cytotoxic effect on cattle lymphocytes, while PBP is lytically active. PBP can lyse all types of blood cells, but only in the absence of serum. Individual differences in the lytic sensitivity of cattle erythrocytes are not correlated with the lytic sensitivity of leukocytes. The lytic activity of PBP against leukocytes is increased in the surroundings of oestrual cervical mucus. Seminal plasma has lytic activity, too. Oestrual cervical mucus and ovarian follicular fluid have also immunosuppressive activity demonstrated by the inhibition of mitogenically stimulated lymphocytes.

R. Matousek, R. Stanek, J. Riha, F. Louda

Proceedings of the World Congress on Genetics Applied to Livestock Production, Volume XI. Genetics of reproduction, lactation, growth, adaptation, disease, and parasite resistance., , 101–106, 1986
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