A review of the most widely used highly inbred lines dates back to the 1930's and 1940's. In spite of their relatively low reproductive performance, these lines have played an important role in research on disease resistance and immunology. More recently developed highly inbred lines have been reported at the University of California, Davis. Several laboratories also have begun to breed congenic lines with a common inbred background but differing from each other in important major genes, such as the haplotypes of the major histocompatibility complex. Problems relating to the maintenance of isogenic lines are discussed with reference to the standards set for highly inbred lines of laboratory mammals. The value of highly inbred lines for research increases as their biological properties are defined in more and more detail. Published summaries of these characteristics in biological handbooks are essential for adequate access by researchers to these genetic resources.
Proceedings of the World Congress on Genetics Applied to Livestock Production, Volume X. Breeding programs for swine, poultry, and fish., , 257–272, 1986
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