The realized rate of inbreeding and effective population size (Ne) were studied in eight control populations of mice of different origins each maintained in two environments. The main populations were kept under a controlled environment with 25 single pair matings for 70 generations. One replicate from each population kept in an environmentally uncontrolled laboratory with 15 single pair matings. One male and one female were selected for breeding from each family and used in a cyclical mating system. The realized inbreeding coefficient showed a repeating_pattern of rises and falls over generations. The realized Ne's were 33.7% to 65.5% smaller than the expected in^ different populations. Unequal contribution of different families to the next generation resulted in the variance of family size being larger than zero in almost all generations in all the populations. The genetically heterogeneous populations had smaller variance of family size and larger Ne in both environments compared with those which had longer history of inbreeding. 

A. Farid, M. Makarechian, J. A Newman

Proceedings of the World Congress on Genetics Applied to Livestock Production, Volume XII. Biotechnology, selection experiments, parameter estimation, design of breeding systems, management of genetic resources., , 303–308, 1986
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