Two designs, denoted the "daughter" and "granddaughter" designs, are presented to detect QTL of moderate magnitude in outcrossing populations. The granddaughter design was twice as powerful as the "daughter” design, but still requires genotype determination on several hundred to several thousand individuals to achieve power of .5 to detect a quantitative trait loci responsible for 1% of the phenotypic variance. Previous studies have shown that in crosses between inbred lines, power can be increased by selective genotyping, marker brackets, and analysis by maximum likelihood techniques. The likelihood function is presented for the daughter design, and methods are discussed for ML hypothesis testing and parameter solution. The effects of these techniques on analysis of segregating populations has not yet been studied.
Proceedings of the World Congress on Genetics Applied to Livestock Production, Volume XIII. Plenary lectures, molecular genetics and mapping, selection, prediction and estimation., , 113–116, 1990
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