Enzootic bovine leukosis (EBL) is a complex lymphoproliferatlve disease that has a significant Impact on the dairy and beef cattle Industries worldwide. The development of EBL Is associated with chronic Infection by the bovine leukemia virus (BLV). Some of the major features of the pathogenesis of BLV Infection Include: a) a variable period between the time of Infection and seroconversion to the major viral envelope protein, BLV- gp51; b) proliferation of virus-infected B cells which results In a persistent B-cell lymphocytosis (PL) in approximately 1 /3 of BLV-Infected cattle; c) the appearance of antibodies to the viral core protein, p24, which is associated with the development of PL, and d) clinical lymphosarcoma, which develops In only 1 to 5% of BLV Infected cattle.

H. A Lewin

Proceedings of the World Congress on Genetics Applied to Livestock Production, Volume XVI. Poultry, fish and horse genetics and breeding, growth and reproduction, immune response and disease resistance., , 465, 1990
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