We have shown that natural resistance to a standardized challenge of B. abortus in nonvaccinated cattle is heritable. Immune parameters that correlate with the natural resistance (R) and susceptible (S) phenotypes are: (a), macrophage (Mo) control or failure to control B. abortus replication in vitro; (b). response of oligoclonal T lymphocyte cell lines to various species of Brucellae; and (c) the IgG2a- A1 & A2 allotypic postchallenge antibody response to B. abortus LPS.
Proceedings of the World Congress on Genetics Applied to Livestock Production, Volume XVI. Poultry, fish and horse genetics and breeding, growth and reproduction, immune response and disease resistance., , 396–399, 1990
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