The experimental procedures for assessing the contribution of contemporaneous bursts of transposition to short-term selection response in the Drosophila/P element model system are reviewed. Using the only satisfactory procedure, involving inbred M stocks and co-isogenic P stock transformants, substantial selection responses attributable to transpositional mutation were obtained for abdominal bristle number and inebriation resistance. Vm/Vp ratios for abdominal bristle number averaged 0.045 (range 0.0025-0.105) for the transposition lines, 45 times greater than the usual rate of 10- 3 for spontaneous mutation (Lynch, 1988). Realised heritability due to transposition in these inbred lines averaged 14% (range 0-25%). For inebriation resistance/susceptibility, transposition significantly affected selection for increased time to inebriation (regression of deviation from control means on generation of 0.266+0.089, 0.245±0.109), whereas no significant response was obtained for decreased time to inebriation.
These results, obtained using stocks of flies transformed by microinjection, are of immediate relevance to domestic animal species, some of which have transposable elements which could be perturbed in a similar way. Furthermore any quantitative trait loci producing selection responses as a result of transposition are, ipse facto, identifiable and clonable.
Proceedings of the World Congress on Genetics Applied to Livestock Production, Volume XIII. Plenary lectures, molecular genetics and mapping, selection, prediction and estimation., , 229–237, 1990
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