We.*lav? transgenic chickens that carry a CNA copy of the avian leukosis virus (ALV) genome as a stable chromosomal element. Of 23 families produced two failed to produce infectious ALV, but did express the envelope glycoprotein of ALV on the cell surface. These two germ-line inserts acted as dominant genes for resistance to ALV in cell culture and one of them was shewn to induce resistance to infection and oncogenesis in animals. This is an exauple of pathogen-derived resistance as proposed by Sanford and Johnston (1985). We prepose that this general concept can be used to induce resistance to other pathogens and in other species.
Proceedings of the World Congress on Genetics Applied to Livestock Production, Volume XVI. Poultry, fish and horse genetics and breeding, growth and reproduction, immune response and disease resistance., , 453–456, 1990
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