Changes of genetic variance and frequencies at marker loci are described for an experiment on divergent selection on 6 week weight of mice which used a cross between two inbred strains as its base population. Estimates of genetic and environmental components of variation were obtained from the regression of response on within family selection differential and by animal model REML. Heritabilities estimated by both methods were about 0.2, and in close agreement. Despite the limited genetic base, there was substantial genetic variance. A model was fitted in which variance components were allowed to vary in different time periods and between sets of lines. This analysis suggested that the genetic variance increased substantially during the latter stages of the selection experiment. In several regions of the genome, marker alleles diverged in frequency between the high and low line replicates to a greater extent than would be expected by chance, suggesting the presence of QTL with effects of at least 0.3 phenotypic standard deviations.

P. D Keightley, S. C Heath, T. Hardge, I. May, Alan L Archibald, G. Bulfield

Proceedings of the World Congress on Genetics Applied to Livestock Production, Volume 19. Selection and quantitative genetics; growth; reproduction; lactation; fish; fiber; meat., , 61–66, 1994
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