The full complement of cis-active DNA sequences for the control of transcription of the chicken lysozyme gene was determined. The functional unit comprises a 21 kb chromatin domain containing the gene, all regulatory elements and 5' and 3' domain border regions. The lysozyme gene domain DNA is able to mediate consistantly correct cell type specific gene expression, is able to overcome genomic position effects and is a potential vector for the production of foreign proteins in the avian egg.

A. E Sippel, H. Saueressig, N. Faust, G. Schafer, C. Bonifer

Proceedings of the World Congress on Genetics Applied to Livestock Production, Volume 21. Gene mapping; polymorphisms; disease genetic markers; marker assisted selection; gene expression; transgenes; non-convention, , 307–313, 1994
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