Information on linkage between a marker and a locus affecting a quantitative trait has to be accumulated on a within-family basis. In the analysis of livestock linkage experiments it is important to account for variation due to genes not linked to the marker. New ways to tackle these complicated genetic models are described. An animal model is described for BLUP of additive effects at the marked QTL and additive effects of polygenes. Influence of number and effects of alleles at the QTL on cumulative genetic gam using marker assisted selection are determined. The BLUP approach was found to be a robust method and it can account for differences in allelic effects at a QTL as a result of interactions with background genotypes or with environmental conditions. Close linkage between markers is expected to be advantageous but will not circumvent the need to use marker QTL associations within families.
Proceedings of the World Congress on Genetics Applied to Livestock Production, Volume 21. Gene mapping; polymorphisms; disease genetic markers; marker assisted selection; gene expression; transgenes; non-convention, , 193–200, 1994
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