Transgenic mice possessing an ovine growth hormone gene were used as a model to study the effects of elevated growth hormone levels on heritabilities of production traits. Male mice hemizygous for the transgene were mated to wild type females to produce half- and full-sib families in which approximately half the progeny were transgenic and half were wild type. Heritabilities for growth and carcass traits were then estimated for each genotype group. At 10 weeks, body weight of transgenics exceeded that of wild types by 26 and 50% in males and females, respectively. Heritabilities for body weight gains from 6 weeks to 10 weeks of age, and for epididymal fat pad and hind carcass weights as a percentage of body weight, tended to be greater for transgenics than for wild types. These results indicate that elevated growth hormone levels may alter the genetic control of production traits and potential response to selection.

A. C Clutter, D. Pomp, J. D Murray

Proceedings of the World Congress on Genetics Applied to Livestock Production, Volume 21. Gene mapping; polymorphisms; disease genetic markers; marker assisted selection; gene expression; transgenes; non-convention, , 366–369, 1994
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