Advanced intercrossed generations (AIG) is an experimental design that can provide more accurate estimates of QTL map location by means of linkage analysis. AIG are produced by randomly and sequentially intercrossing a previous generation, which initially originated from an F2 population. This provides increasing probability of recombination between any two loci. Consequently, the genetic length of the entire genome is stretched, providing a better mapping resolution. A 95% confidence interval of QTL map location of 20 cM in the F2 is reduced to 3.7 cM after 8 additional generations (F10), analyzing the same population size for the same QTL. AIG derived from crosses between known inbred lined may be an attractive resource for fine mapping of QTL.
Proceedings of the World Congress on Genetics Applied to Livestock Production, Volume 21. Gene mapping; polymorphisms; disease genetic markers; marker assisted selection; gene expression; transgenes; non-convention, , 21–24, 1994
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