Chicken growth hormone ( GH ) receptor gene was isolated from a genomic library, and its promoter region and several exons have been sequenced. The coding fragments span about only 10 kilobase, nnliv^ the human GH receptor gene, which spans at least 87 kilobase. Sex-linked dwarfism m chicken is a recessive genetic disorder that is characterized bv undetectable levels of hepatic GH-binding activity and a mutation in the GH receptor gene. With the region specific DNA probes from our genomic cloning, characterization of the GH receptor gene indicates that sex-linked dwarf chickens have a deletion of approximately 2 kilobase portion in the intracellular domain of the receptor gene. These direct evidence demonstrate that sex-linked dwarfism could result from a defeat in the structural gene of the GH receptor gene in chicken
Proceedings of the World Congress on Genetics Applied to Livestock Production, Volume 21. Gene mapping; polymorphisms; disease genetic markers; marker assisted selection; gene expression; transgenes; non-convention, , 13–16, 1994
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