A least squares method using multiple markers for the detection of quantitative trait loci is presented for the analysis of data from half-sib populations. A simulation study illustrates the benefits in power of this method over one using markers one at a time. The multiple marker method provides reasonable estimates of location for the QTL with smaller standard deviation than those obtained using the markers one at a time. The method provides a rapid and relatively powerful way of locating genomic regions containing QTLs for more detailed analysis.

Sara A Knott, Jean-Michel Elsen, Chris S Haley

Proceedings of the World Congress on Genetics Applied to Livestock Production, Volume 21. Gene mapping; polymorphisms; disease genetic markers; marker assisted selection; gene expression; transgenes; non-convention, , 33–36, 1994
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