Evaluation of different species and breeds in different breeding situations and environments have demonstrated the possibility of breeding for nematode resistance (Gray, 1997; Gauly et al., 2001; Gauly and Erhardt, 2001). The identification of genetically resistant animals could be facilitated if the genomic loci responsible for the majority of the genetic variation in host resistance would be known. In addition, the identification of genes which regulate resistance would improve our understanding of the mechanisms of host defence against parasites and could accelerate the development of efficient vaccines. Hints for genetic resistance in sheep against Haemonchus contortus are given by studies of Bouix et al. (1998) and Outteridge et al. (1996) for example. Associations in Soay sheep between resistance to intestinal nematodes and OLADRB alleles which is a genetic marker belonging to the Major Histocompatibility Complex (MHC) were demonstrated (Paterson et al., 1998). The MHC is located to ovine chromosome 20 (De Gortari et al., 1998). Further on associations between MHC and eggs per gram of faeces (EpG) were demonstrated for Ostertagia circumcincta (Schwaiger et al., 1995) and Trichostrongylus colubriformis (Luffau et al., 1986). However associations between genetic markers and Haemonchus contortus infections have so far not been estimated. The aim of this study was to calculate associations between parameters of parasite resistance and genetic markers on OAR 20. 

M. Janssen, C. Weimann, M. Gauly, G. Erhardt

Proceedings of the World Congress on Genetics Applied to Livestock Production, Volume 2002. Session 13, , 13.11, 2002
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