Abstract

Gastro-intestinal nematodes are arguably the most important disease restricting domestic ruminant production (McLeod, 1995). Control rests heavily on chemotherapy but resistance to anthelmintic drugs by the parasites poses a major threat to livestock industries worldwide (Waller, 1997). An alternative is to produce through selective breeding or genetic modification stock with enhanced resistance to infection (Woolaston and Baker, 1996). Rodent infections provide valuable models to analyse factors controlling resistance to economically important gastro-intestinal nematode parasites (Wakelin, 2000 ; Behnke et al., 2000). Resistance and susceptibility in mice are genetically determined making it possible to identify genetic markers and then look for homologues in target ruminants (Kemp et al., 1997 ; Kemp and Teale, 1998) or humans (Blackwell, 1996). We report here mapping of quantitative trait loci (QTL) for resistance to Helgmosomides polygyrus in mice, a strongyloid worm whose biology is similar to the trichostrongyloid nematodes of economic importance in domestic ruminants. 

D. M Menge, J. M Behnke, F. Iraqi, A. Lowe, A. J Teale, John P Gibson, D. Wakelin, R. L Baker

Proceedings of the World Congress on Genetics Applied to Livestock Production, Volume 2002. Session 13, , 13.26, 2002
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