Abstract

Myostatin is a key negative regulator of muscle growth that belongs to the transforming growth factor-β super family (McPherron et al., 1997). In mouse, deletion of this gene by homologous recombination results in a 2-3 fold increase in muscle mass (McPherron et al., 1997), while in cattle (Grobet et al., 1997; McPherron and Lee, 1997 ; Grobet et al., 1998) and mouse (Szabó et al., 1998) selected for muscle deposition, natural mutations in this gene are associated with muscle hypertrophy and hyperplasia. Moreover, reduced muscle use (Wehling et al., 2000) or muscle-wasting conditions in patients with HIV infection (Gonzales-Cadavid et al., 1998) increase myostatin gene expression. Despite its importance for muscle growth and maintenance, little is known about the ontogeny and spatial distribution of myostatin

L. L Coutinho, E. C Castelhano-Barbosa, J. E Gabriel, L. E Alvares, C. B Monteiro-Vitorello

Proceedings of the World Congress on Genetics Applied to Livestock Production, Volume 2002. Session 15, , 15.07, 2002
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