The three equine genes for the cysteine-rich secretory proteins (CRISP1, CRISP2, CRISP3) were investigated as candidate genes for stallion fertility traits. After cloning and sequencing the degree of naturally occurring variation within the CRISP genes was determined. Resequencing of all 26 CRISP exons in a sample of 16 diverse horses revealed 105 polymorphisms within or closely adjacent to CRISP exons. Six of these polymorphisms led to amino acid exchanges in the encoded CRISP proteins. The six non-synonymous polymorphisms were genotyped in a sample of 107 Hannoverian breeding stallions. An association analysis of stallion fertility and CRISP genotype indicated that one particular haplotype within the CRISP3 gene was associated with decreased fertility in the analyzed 107 breeding stallions.
Proceedings of the World Congress on Genetics Applied to Livestock Production, Volume , , 08.01, 2006
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