Theoretical properties of the inheritance of chromosome segments of a given genetic length (in Morgan) are derived, and it is shown that in a closed population the chromosome segment homozygosity (CSH) approaches an equilibrium value, which depends on segment length and population size. Selection leads to an excess of CSH in the proximity of a QTL under selection pressure. In a simulation study it is shown, that this excess CSH is only observable in a certain time window and with a specific genetic resolution, which both depend on the segment length chosen. Longer segments cause significant signals of selection over a wider genetic distance and more generations of selection. The suggested approach is an extension of single-locus based methods for detection of selection signals and makes no use of phenotypic classifications (e.g. healthy vs. diseased) or specific haplotypes. It may proof especially useful when dense SNP genotypings will be available for populations under differing selection pressure.

Henner Simianer, C. Flury

Proceedings of the World Congress on Genetics Applied to Livestock Production, Volume , , 21.02, 2006
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