To develop and investigate a strategy to maximize response while conserving diversity and controlling inbreeding, an optimal strategy that maximized the average breeding value of the selected individuals with a penalty on the number of QTL losing the favorable allele was applied. A trait with 100 additive QTL in a population with 5 sires, 10 dams and 20 offspring per family was simulated. All QTL and their effects were assumed known. Optimal selection led to a lower number of QTL lost, a higher average frequency of favorable alleles, lower response in early generations but higher response in later generations, and about 10-30% lower inbreeding than truncation selection on breeding value. Thus, with availability of QTL information, selection with a restriction on the number of QTL lost can be used to conserve QTL diversity, increase long-term benefits and reduce inbreeding in animal breeding programs.
Proceedings of the World Congress on Genetics Applied to Livestock Production, Volume , , 22.17, 2006
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