The viral disease Pancreas Disease (PD) is currently one of the most problematic diseases on Atlantic salmon farms. The aim of this study was to explore the genetic architecture of PD resistance. In a population of 5,558 PD-challenged Atlantic salmon fry from 218 full-sib families, the heritability of PD mortality was estimated to be 0.5. Resistance QTL were mapped using a two-step approach, utilizing the disparity in recombination rates between the sexes in salmon. First, using a sparse SNP map and sire-based linkage analyses, one genome-wide significant QTL was mapped to chromosome 23, while two chromosome-wide significant QTL mapped to chromosomes 3 and 7. Second, a denser panel of SNPs on significant chromosomes and a dam-based analysis was used to confirm a QTL on chromosome 3 and estimate QTL positions. Further work to characterize these QTL is underway.
Proceedings of the World Congress on Genetics Applied to Livestock Production, Volume Species Breeding: Breeding in aquaculture species, , 262, 2014
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