Complex traits are presumably affected by several genomic regions acting in some concerted manner (epistasis), by non-linearity between genome and phenotypes stemming from enzyme kinetics, and by interactions with environmental forces. Prompted by these considerations, non-parametric approaches entered into quantitative genetics early in the 21st century, and a decade of experience has been accumulated, mostly in animals and plants. Some developments are reviewed in this paper, and areas for additional investigation are discussed.
Proceedings of the World Congress on Genetics Applied to Livestock Production, Volume Methods and Tools: Statistical methods - linear and nonlinear models, , 212, 2014
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