The objective of this investigation was to perform a genome-wide association study to identify chromosomal regions associated with loin marbling score (LMS) in Duroc pigs. A Generalized quasi-likelihood scoring test and a 10% false discovery rate at chromosome-wise level were used to identify the SNPs associated with LMS estimated breeding values. A total of 35 SNPs located on chromosomes 3, 5, 9, 10 and 18 were significantly associated with LMS and 47 genes were mapped either harboring or being next to these SNPs. Some of the significant SNPs were located close to or within genes (APOB, SORL1, SC5DL, FGF23, GRIK4, CLCN1) that play role in biological processes and pathways, related to lipid metabolism and fat deposition, which were significantly enriched in functional analyses. The identified genes are potential candidate genes for the underlying genetic variation in marbling score in Duroc pigs.
Proceedings of the World Congress on Genetics Applied to Livestock Production, Volume Genetic Improvement Programs: Selection using molecular information (Posters), , 451, 2014
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