Bovine tuberculosis (bTB) has been among the most persistent diseases in cattle.  Genetic selection of resistant individuals may be a complementary approach for disease control. The aim of this study was to conduct a meta-analysis on two dairy cattle populations with bTB phenotypes and SNP chip genotypes, identifying genomic regions underlying bTB resistance and testing genomic predictions by means of cross-validation. We identified a region on chromosome 6 likely to be associated with bTB resistance and confirmed that this chromosome as a whole contributes a major proportion of the observed variation in dataset. Genomic prediction for bTB was shown to be feasible even when different populations are combined, with the chromosome heritability results suggesting that the accuracy arises from the SNPs capturing linkage disequilibrium between markers and QTL as well as additive relationships between animals. Further studies on larger populations will be needed to confirm findings.

Smaragda Tsairidou, John A Woolliams, Adrian Allen, Robin Skuce, Stewart H McBride, Ricardo Pong-Wong, Oswald Matika, Emma Finlay, Donagh P Berry, Dan Bradley, Stanley McDowell, Elizabeth Glass, Stephen C Bishop

Proceedings of the World Congress on Genetics Applied to Livestock Production, Volume Genetics of Trait Complexes: Disease resistance, , 102, 2014
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