Porcine Reproductive and Respiratory Syndrome (PRRS) is an important disease of pigs. Sow farrowing and service data were obtained from two commercial pig multiplication units which experienced several confirmed PRRS outbreaks. Genomic regions associated with reproductive failure during PRRS outbreaks were investigated using a regional heritability mapping (RHM) approach combining the two datasets. Covariates were explored both fitting and ignoring the shape of the epidemic. Heritability (h2) of farrowing mortality (FMOR, proportion of dead piglets per litter) was 0.084 ignoring the epidemic shape and 0.059 fitting it. The additive genetic variance was non-estimable for the FMOR trait during non-epidemic phase. Two regions were significantly associated with FMOR at the genome-wide level, on Sus scrofa chromosomes (SSCs) 4 and 7, with several other regions approaching significance. A single SNP on SSC4 was significantly associated (P<0.001) with FMOR.

Christopher M Orrett, Nader Deeb, Ricardo Pong-Wong, Oswald Matika, Craig RG Lewis, David G McLaren, Alan L Archibald, Stephen C Bishop

Proceedings of the World Congress on Genetics Applied to Livestock Production, Volume Genetics of Trait Complexes: Disease resistance, , 100, 2014
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