Fertility is a key functional trait in dairy production systems, because calving determines the beginning of milk production. The objective of this study was to detect genomic regions associated with four fertility parameters: days at first service (D1S), calving interval (CI) number of services per conception (NSC) and days open (OD) to provide tools for improvement of the selection process. Phenotypes were the breeding values of D1S, CI, NSC and OD with reliabilities greater than 0.30 of Mexican Holstein females born from 2008 to 2013. After the genotype’s quality control, a total of 20,407 SNP and 3,242 animals were used to perform Genome Wide Association Studies (GWAS) through a single linear regression model, previously adjusting for population composition and counting for false discovery rate and Bonferroni’s correction. Quality control and GWAS were performed with SVS Golden Helix V.8.6. Hundreds of significant SNP (<1*e-5) were associated to fertility traits in the Mexican Holstein population. Because several genomic regions were related with many traits, the 100 most significant SNPs for each trait were pooled together and the SNP associated with more than two traits were referenced in the genomic databases. Six of the nine SNP associated in this study with more than two traits, were previously reported in other populations. Three of them are related directly with fertility (The SNP ARS-BFGL-NGS-101016 with calving index and calving ease, Hapmap31053-BTA-111664 with number of inseminations and non-return rate and ARS-BFGL-NGS-103755 with calf size). Another three SNP have not been linked to fertility, but instead are related with traits for which a negative relationship with it has been reported like some production traits (for example, the marker ARS-BFGL-NGS-24522, SNP is related with caseins yield, BTB-01869907 with milk, fat, protein and lactose yield and Hapmap44709-BTA-70915 with mature weight). Markers BTB-02009158, ARS-BFGL-NGS-115837 and ARS-BFGL-NGS-113691 from chromosomes 8, 14 and 22 respectively, have not been previously associated to traits or genes that explain a possible interaction with fertility. This study shows the presence of novel genomic regions associated with fertility parameters in Holstein cattle. Keywords: Genomic regions, fertility traits, Mexican cattle.
Proceedings of the World Congress on Genetics Applied to Livestock Production, Volume Electronic Poster Session - Biology & Species - Bovine (dairy) 1, , 198, 2018
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