Genome-wide association for facial eczema tolerance in New Zealand sheep K.M. McRae1, S.M. Clarke1, T.J. Johnson1, H.J. Baird1, S-A.N. Newman1, K.G. Dodds1, J.C. McEwan1 & S.J. Rowe1 1 AgResearch Invermay, Private Bag 50034, Mosgiel 9053, New Zealand kathryn.mcrae@agresearch.co.nz (Corresponding Author) Facial eczema (FE) is a metabolic disease of great importance to the New Zealand sheep industry. Liver and bile duct damage, caused by ingestion of the mycotoxin sporidesmin, results in photosensitisation, and reduced production. There is genetic variation in tolerance to facial eczema, and breeding programs have been successful in making genetic progress. The objective of this study was to utilise large phenotypic datasets in conjunction with low density genotypes, to interrogate the sheep genome for regions associated with variability in tolerance to facial eczema. A QTL on chromosome 15 at the β-globin locus is reported which explains 8% of the genetic variance. Haemoglobin haplotypes have previously been associated with variation in a number of health related traits in sheep. Keywords: sheep, disease, facial eczema

Kathryn McRae, Shannon Clarke, Tricia Johnson, Hayley Baird, Sheryl-Anne Newman, Ken Dodds, John McEwan, Suzanne Rowe

Proceedings of the World Congress on Genetics Applied to Livestock Production, Volume Biology - Disease Resistance 2, , 466, 2018
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