The aim of this research was to perform a genome-wide association study (GWAS) for milk traits: milk yield (MY), fat yield (FY) and protein yield (PY), in Philippine dairy buffaloes and identify significant single nucleotide polymorphisms (SNPs) associated with these traits. Phenotypes used were first parity 305-day records for milk yield (MY), fat yield (FY) and protein yield (PY) of 503, 451 and 465 dairy buffaloes. GWAS was performed using genotypes of 503, 451 and 465 females for MY, FY and PY, respectively, from the Axiom 90k Buffalo Genotyping Array. The model for GWAS fitted fixed effects of breed, herd, year of calving, season of calving and SNP-genotype as well as a polygenic effect with a covariance structure proportional to a matrix with genomic relationships among animals. SNPs with a p-value < 0.0001 were considered significant. Seven, nine, and six SNPs were identified to be associated with MY, FY and PY, respectively. Of these SNPs, 16 are associated to 1 trait only, while 3 are associated to two traits. The above SNPs can be used as part of a genetic selection program of the PCC to improve milk traits in dairy buffaloes. Keywords: genome-wide association study, dairy buffalo, buffalo genotyping array

Jesus Rommel Herrera, Ester Flores, Naomi Duijvesteijn, Cedric Gondro, Julius Van Der Werf

Proceedings of the World Congress on Genetics Applied to Livestock Production, Volume Species - Other, , 825, 2018
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