The aim of this study was to identify genomic regions associated with omega 3 (n3), omega 6 (n6) and ratio of n6/n3 fatty acids in intramuscular fat of Nellore cattle using haplotype blocks. The investigated dataset contained records from 963 Nellore steers. After genomic quality control, 469,981 SNPs and 893 animals were available for the analyses. Haplotype blocks were defined based on linkage disequilibrium. Genome-wide association analyses were performed considering one haplotype at a time. A total of 83,957 haplotypes were included in the genome-wide association analyses. From those haplotypes, 115, 25 and 66 were significantly associated (genome-wide p < 0.05) with n3, n6 and ratio n6/n3, respectively. These significant regions harbor 35 genes related to fatty acids. These results may contribute to further investigations aiming to generate tools for selecting Nellore cattle with improved beef fatty acid composition for better flavor and improved human health. Keywords: Beef quality, candidate genes, haplotypes, Nellore cattle

Fabieli Loise Brag Feitosa, Camila Urbano Braz, Marcos Vinicius A Lemos, Mariana Piatto Berton, Rafael Medeiros d Silva, Rafael Lara Tonussi, Elisa Peripolli, Bianca Ferreira Olivieri, Angelica Simone Cra Pereira, Lucia Galvão Albuquerque, Flavio Schramm Schenkel, Fernando Baldi

Proceedings of the World Congress on Genetics Applied to Livestock Production, Volume Electronic Poster Session - Species - Bovine (beef) 2, , 645, 2018
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