Abstract

Heat stress of dairy cattle could cause considerable economic loss due to unfavorable correlation with production, reproduction, and immunity. Rectal temperature (RT) is widely used as an indicator of heat stress in dairy cattle. This study was aimed to screen quantitative trait loci (QTL) for RT during heat stress in lactating Holstein cows using Genome-wide Association Study (GWAS). The whole genomic single nucleotide polymorphisms (SNPs) were obtained from the Illumina BovineSNP150 BeadChip genotyped on 1,114 individuals. Estimated breeding values (EBVs) were derived for morning RT (AMRT) and afternoon RT (PMRT). Only the AMRT was used to perform GWAS by using the Fixed and random model Circuitous Probability Unification (FarmCPU) method. In total, 8 SNPs were identified to be significantly associated with AMRT. We found 5 candidate genes located nearby the associated SNPs. The genes FAM107B and PHRF1 were concluded to be strong candidate genes. Keywords: Chinese Holstein, rectal temperature, genome-wide association study

Hanpeng Luo, Wei Xu, Aoxing Liu, Xizhi Li, Lin LIU, Yachun Wang

Proceedings of the World Congress on Genetics Applied to Livestock Production, Volume Electronic Poster Session - Methods and Tools - GWAS, , 587, 2018
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