Proceedings of the World Congress on Genetics Applied to Livestock Production, 11. 205. QTLs mapped by selective DNA pooling explain substantial proportion of phenotypic and genetic variation in MD mortality in chicken layer lines Ehud Lipkin1, Jacqueline Smith2, Dave Burt2, Morris Soller1, Janet E. Fulton3 1 Dept. of Genetics, Silberman Life Sciences Institute, The Hebrew University of Jerusalem, Jerusalem 91904, Israel ehud.lipkin@mail.huji.ac.il (Corresponding Author) 2 The Roslin Institute and Royal (Dick) School of Veterinary Studies, The University of Edinburgh, Easter Bush, Midlothian EH25 9RG, UK 3 Hy-Line International, PO Box 310, Dallas Center, IA 50063, USA Marek’s disease (MD) has a major effect on poultry health, production and welfare. Intensive use of vaccines is driving the virus to increasing virulence. New, more virulent strains continue to emerge, calling for other control means, such as selective breeding. In the present study we estimated the effects of MD QTLs mapped by selective DNA pooling in 8 chicken layer lines, and estimated the QTL contribution to the within-line phenotypic and genetic variation. The absolute effects of the QTLs were appreciable, substantially contributing to the phenotypic variation, and in some lines accounting for up to 100% of the genetic variation of sire progeny test for MD mortality. Keywords: Marek's disease, Selective DNA pooling, GWAS, allele effect, genetic variation

Ehud Lipkin, Jacqueline Smith, Dave W Burt, Moshe Soller, Janet Fulton

Proceedings of the World Congress on Genetics Applied to Livestock Production, Volume Biology - Disease Resistance 3, , 205, 2018
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